Guiding stem cell differentiation into oligodendrocytes using graphene-nanofiber hybrid scaffolds.

Herein, we report the use of a graphene-based nanomaterial for the design of hybrid nanofi brous scaffolds to guide NSC differentiation into oligodendrocytes ( Figure 1 ). Graphene-based nanomaterials, such as graphene oxide (GO), have recently gained considerable interest for tissue engineering applications due to their favorable chemical, electrical and mechanical properties. [ 9 ] Besides serving as a highly elastic and fl exible structural reinforcement, substrates coated with GO have been demonstrated to promote the growth and differentiation of various stem cell lines, including induced PSCs, MSCs and NSCs. [ 10 ]